The Department of Defense (DoD) operates six forensic urine drug-testing laboratories that screen close to 5 million urine samples for amphetamines yearly. Recently, the DoD laboratories have observed a significant decrease in the confirmation rates for amphetamines because of specimens screening positive by two separate immunoassays and confirming negative by gas chromatography-mass spectrometry (GC-MS). Previous studies conducted by the Division of Forensic Toxicology, Armed Force Institute of Pathology (AFIP) utilizing a GC-MS basic drug screen and a designer drug screen revealed no common compound or compound classes as to the cause of the immunoassay-positive results. Additional information obtained from an immunoassay vendor suggested the anorectic compound dimethylamylamine (DMAA) may be the cause of the false-positive screens. An additional 134 false-positive samples were received and analyzed using liquid chromatography-tandem mass spectrometry (LC-MS-MS) for DMAA. LC-MS-MS analysis revealed the presence of DMAA in 92.3% of the false-positive samples at a concentration of approximately 6.0 mg/L DMAA, causing a positive screen on both immunoassay kits. [1]
Based off of these findings we can clearly see that a false positive is highly likely in any situation. The body is roughly 6 Liters which means only 36 mg would be needed for a false positive. If a common pre workout contains 40 mg of DMAA you can false positive for meth amphetamine.
- Vorce SP, Holler JM, Cawrse BM, Magluilo J Jr. (april 2011) Dimethylamylamine: a drug causing positive immunoassay results for amphetamines. retrieved. http://www.ncbi.nlm.nih.gov/pubmed/21439156
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